Can TMS Make Depression Worse

TMS is a safe, FDA-approved treatment for depression, but some patients experience a temporary “TMS dip.” Learn why this happens, whether TMS can worsen depression long-term, and how Quantum Wellness Center supports safe, effective treatment.

Transcranial Magnetic Stimulation (TMS) is a non-invasive treatment option approved for depression, especially for individuals who haven’t responded to medication. A common concern is whether TMS could potentially worsen depression. 

This article takes a clear and direct look at this question, exploring the potential effects, why some people experience worsening symptoms, and what patients should expect throughout treatment.

Can TMS worsen depression

Understanding TMS Therapy and How It Works

TMS therapy, or transcranial magnetic stimulation, uses magnetic pulses to stimulate nerve cells in areas of the brain associated with mood regulation. It is FDA-approved and primarily used for individuals with treatment-resistant depression. During a TMS session, repetitive transcranial magnetic stimulation is applied using a device placed near the scalp, targeting the prefrontal cortex.

This stimulation helps rewire neural circuits and improve symptoms of depression. It is considered a safe and effective option for many patients, with a growing body of research showing its success in reducing overall distress. Despite its promise, like any mental health treatment, individual responses vary.

If you’re considering rTMS therapy as a depression treatment option, it’s helpful to speak with a trusted provider like Quantum Wellness Center, who can guide you through the process and answer any questions along the way.

What Is the TMS Dip and Why Does It Happen

Some patients report a temporary worsening of depression symptoms after starting TMS therapy—a phenomenon often referred to as the “TMS dip.” This can occur during the first week of treatment or even later in the course. The dip does not mean the treatment is failing. Although it can be discouraging, it is often a sign that the brain is beginning to respond to the magnetic stimulation.

This phase is usually short-lived, and most individuals see gradual improvement in depressive symptoms as the course of treatment continues. The exact cause is unclear, but it may relate to how the brain adapts to stimulation. Just like with antidepressants, changes in neural activity can temporarily destabilize mood before the desired therapeutic effects kick in. Fortunately, most patients who experience it go on to show improvement with continued treatment.

Can TMS Worsen Depression Permanently?

There is little evidence to suggest that TMS can make depression worse in the long term. While a small number of patients may not respond or may report negative experiences with TMS, research consistently shows that it is an effective treatment, especially for patients with treatment-resistant depression.

The key is distinguishing between a temporary dip in mood (such as the TMS dip) and a persistent worsening of depression and anxiety. In cases where symptoms worsen and do not improve, it is crucial to assess whether the treatment protocol is appropriate, if adjustments are needed, or if another mental health condition may be influencing the outcome. Monitoring by a qualified TMS provider is essential.

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Understanding the Side Effects of TMS Treatment

TMS is generally well-tolerated, but like all mental health treatments, it comes with potential side effects. The most common include scalp discomfort during stimulation, mild headaches, and lightheadedness. These usually resolve as treatment progresses.

More serious side effects of TMS treatment, such as seizures, are extremely rare. Emotional sensitivity or mood fluctuations may also occur, particularly in the early stages of treatment. While these reactions may feel like a worsening of depression, they are usually temporary and manageable with proper clinical oversight.

It is important to receive rTMS from a qualified and experienced provider who can monitor progress and make adjustments as needed.

When to Seek Support During TMS Therapy

While most patients find TMS therapy to be a safe and effective treatment for depression, anyone experiencing worsening symptoms should communicate openly with their care team. If depressive symptoms or anxiety symptoms intensify or begin to affect daily life, a reassessment of the treatment session protocol may be necessary.

Patients undergoing TMS therapy should also be aware of other factors that can affect progress, such as medication interactions, untreated co-occurring disorders, or high levels of daily stress. Working with a supportive clinical team ensures that adjustments can be made and outcomes improved.

It is also important to note that the benefits of TMS often accumulate gradually, and commitment to the full course of treatment is key to experiencing long-term relief.

Final Thoughts from Quantum Wellness Center

TMS does not worsen depression in the long term, though some individuals may experience temporary mood fluctuations or discomfort during the early stages of treatment. With proper supervision, these effects are manageable and rarely interfere with long-term benefits.

At Quantum Wellness Center, our team provides evidence-based care with a focus on safety and personalized treatment. By carefully monitoring each patient’s progress, we ensure rTMS therapy is both effective and supportive for those seeking relief from depression.

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